Bioviva ABD \u015eirketinin Y\u00f6netim Kurulu Ba\u015fkan\u0131 Elizabeth Parrish, \u015firketleri taraf\u0131ndan sa\u011flanan deneysel gen tedavisi sayesinde, do\u011fal ya\u015flanman\u0131n etkilerini ba\u015far\u0131l\u0131 bir \u015fekilde tersine \u00e7eviren d\u00fcnya tarihindeki ilk insan oldu\u011funu iddia ediyor.<\/p>\n
Parrish, ilk olarak 2015\u2019te gen tedavisi ge\u00e7irdi. Tedavi, ya\u015flanman\u0131n \u00f6z\u00fcnde olan kas k\u00fctle azalmas\u0131na kar\u015f\u0131 korunmak ve ya\u015fla ili\u015fkili hastal\u0131klardan dolay\u0131, k\u00f6k h\u00fccre azalmas\u0131 ile m\u00fccadele etmek \u015feklinde tasarlanm\u0131\u015ft\u0131.<\/p>\n
Ba\u015flang\u0131\u00e7ta Parrish\u2019in \u015firketi, gen tedavisinin g\u00fcvenli oldu\u011funu ispatlamak zorundayd\u0131. Sonu\u00e7lar ise herhangi bir insanda telomer uzamas\u0131n\u0131n ilk ba\u015far\u0131l\u0131 kan\u0131t\u0131 olacakt\u0131r. Uzun d\u00f6nemde etkili olabilecek bu sonu\u00e7lar, gerekli olan detayl\u0131 bilimsel bir incelemeye direnmektedir.<\/p>\n
Parrish, \u201cSon tedaviler, kendini g\u00f6steren ya\u015fa ba\u011fl\u0131 hastal\u0131klardan mustarip olan insanlar i\u00e7in s\u0131n\u0131rl\u0131 yararlar sunmaktad\u0131r. Ayr\u0131ca ya\u015fam bi\u00e7imi de\u011fi\u015fimi, bu hastal\u0131klar\u0131n tedavisi sonucu olu\u015fan etkiyi s\u0131n\u0131rland\u0131rm\u0131\u015ft\u0131r. Biyoteknolojideki son geli\u015fmeler en iyi \u00e7\u00f6z\u00fcmd\u00fcr ve e\u011fer bu sonu\u00e7lar kesin do\u011frulu\u011fa yak\u0131nsa, tarih yazm\u0131\u015f olaca\u011f\u0131z\u201d a\u00e7\u0131klamas\u0131nda bulunuyor.<\/p>\n
Parrish daha fazla ara\u015ft\u0131rman\u0131n, metotlar\u0131n\u0131 do\u011frulamak i\u00e7in gerekli oldu\u011fu konusuna kat\u0131l\u0131yor. Buna kar\u015f\u0131n bu sonu\u00e7lar do\u011frulan\u0131rlarsa, \u00e7al\u0131\u015fma bir devrim say\u0131lacakt\u0131r.<\/p>\n
Telomerler nas\u0131l \u00e7al\u0131\u015fmaktad\u0131r?<\/strong><\/p>\n Telomerler, her bir kromozomun u\u00e7lar\u0131nda bulunan k\u0131sa DNA par\u00e7alar\u0131d\u0131r. Bunlar, do\u011fal ya\u015flanma sonucu olu\u015fan eskime konusunda bir \u201ctampon\u201d g\u00f6revi g\u00f6rmektedir. Ancak her h\u00fccre b\u00f6l\u00fcnmesi ile telomerler, kromozomu korumak ad\u0131na gittik\u00e7e k\u0131salmaktad\u0131r. Bu k\u0131salma ger\u00e7ekle\u015fti\u011finde, i\u015flev bozuklu\u011fu sinyali olu\u015fur ve bu sinyal ya\u015flanmaya yol a\u00e7ar.<\/p>\n Parrish\u2019in gen tedavi ba\u015far\u0131s\u0131n\u0131n temeli, beyaz kan h\u00fccrelerindeki (T-lenfositler) telomer uzunlu\u011funa dayal\u0131 olarak hesaplanan skorlarla alakal\u0131d\u0131r. Daha y\u00fcksek telomer skorlar\u0131, \u201cdaha gen\u00e7 h\u00fccreler\u201d anlam\u0131na gelir. 44 ya\u015f\u0131ndaki Parrish, Amerikan toplumunda ayn\u0131 ya\u015f aral\u0131\u011f\u0131ndaki insanlar\u0131n ortalama T-lenfositleri ile k\u0131yasland\u0131\u011f\u0131nda, kendisinin ge\u00e7irdi\u011fi gen tedavisinin i\u015fe yarad\u0131\u011f\u0131n\u0131 ve telomer k\u0131salmas\u0131n\u0131n 20 y\u0131l\u0131n\u0131 geri getirdi\u011fini g\u00f6sterdi\u011fini iddia etmi\u015ftir.<\/p>\n Belirtildi\u011fi gibi, sonu\u00e7lar\u0131n ba\u011f\u0131ms\u0131z bir kaynak taraf\u0131ndan do\u011frulanmas\u0131 gereklili\u011fini vurgulamak \u00f6nemlidir. Bioviva, Parrish\u2019in kan\u0131n\u0131 dikkatli bir \u015fekilde g\u00f6r\u00fcnt\u00fclemektedir ve gelecek aylarda, hatta y\u0131llarda bunu yapmaya devam edecektir. Bunun nedeni ise l\u00f6kositlerde g\u00f6r\u00fclen ba\u015far\u0131n\u0131n, v\u00fccudun di\u011fer doku ve organlar\u0131na d\u00f6n\u00fc\u015ft\u00fcr\u00fclebildi\u011finden ya da basit\u00e7e etkilerin di\u011fer hastalarda g\u00fcvenli bir \u015fekilde tekrarlanabilece\u011finden emin olmakt\u0131r.<\/p>\n <\/p>\n \u00c7eviren: Yusuf S\u00fcrmeli<\/strong><\/p>\n \u0130T\u00dc Molek\u00fcler Biyoloji ve Doktora \u00d6\u011fr.<\/em><\/strong><\/p>\n <\/p>\n Kaynak:<\/strong> http:\/\/www.sciencealert.com\/scientists-claim-they-ve-completed-the-first-successful-gene-therapy-against-human-ageing<\/p>\n","protected":false},"excerpt":{"rendered":" Bioviva ABD \u015eirketinin Y\u00f6netim Kurulu Ba\u015fkan\u0131 Elizabeth Parrish, \u015firketleri taraf\u0131ndan sa\u011flanan deneysel gen tedavisi sayesinde, do\u011fal ya\u015flanman\u0131n etkilerini ba\u015far\u0131l\u0131 bir \u015fekilde tersine \u00e7eviren d\u00fcnya tarihindeki ilk insan oldu\u011funu iddia ediyor. Parrish, ilk olarak 2015\u2019te gen tedavisi ge\u00e7irdi. Tedavi, ya\u015flanman\u0131n \u00f6z\u00fcnde olan kas k\u00fctle azalmas\u0131na kar\u015f\u0131 korunmak ve ya\u015fla ili\u015fkili hastal\u0131klardan dolay\u0131, k\u00f6k h\u00fccre azalmas\u0131 ile […]<\/p>\n","protected":false},"author":1,"featured_media":5362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,231],"tags":[],"class_list":["post-5361","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-molekuler-biyoloji-ve-genetik"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/5361","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=5361"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/5361\/revisions"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=5361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=5361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=5361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}