{"id":58855,"date":"2023-07-17T12:39:09","date_gmt":"2023-07-17T09:39:09","guid":{"rendered":"https:\/\/bilimvegelecek.com.tr\/?p=58855"},"modified":"2023-07-17T16:37:28","modified_gmt":"2023-07-17T13:37:28","slug":"genclik-hapi-mumkun-hale-geldi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2023\/07\/17\/genclik-hapi-mumkun-hale-geldi","title":{"rendered":"Gen\u00e7lik hap\u0131 m\u00fcmk\u00fcn hale geldi!"},"content":{"rendered":"

\u00c7eviren: Nal\u00e2n Mahsereci<\/strong><\/p>\n

Ya\u015flanma ve ya\u015fa ba\u011fl\u0131 hastal\u0131klarla m\u00fccadelede \u00f6n\u00fcm\u00fczde yepyeni bir ufuk var art\u0131k. Harvard T\u0131p Okulu, Maine \u00dcniversitesi ve MIT\u2019den ara\u015ft\u0131rmac\u0131lar, \u00f6nc\u00fc bir \u00e7al\u0131\u015fmayla, h\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirmek i\u00e7in kimyasal bir y\u00f6ntem geli\u015ftirdiler. \u00c7al\u0131\u015fma, h\u00fccreleri gen\u00e7 h\u00fccreler olarak yeniden programlamay\u0131 hedefleyen ilk kimyasal yakla\u015f\u0131m\u0131 i\u00e7eriyor. \u00d6nceden bunun ancak g\u00fc\u00e7l\u00fc gen terapileriyle m\u00fcmk\u00fcn olabilece\u011fi d\u00fc\u015f\u00fcn\u00fcl\u00fcyordu.<\/span><\/p>\n

12 Temmuz 2023\u2019de <\/span>Aging<\/span><\/i>\u2019de yay\u0131mlanan ara\u015ft\u0131rma, \u201cH\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirmek i\u00e7in kimyasal olarak uyar\u0131lm\u0131\u015f yeniden-programlama\u201d ba\u015fl\u0131\u011f\u0131n\u0131 ta\u015f\u0131yor.<\/span><\/p>\n

Ekibin bulgular\u0131, Yamanaka fakt\u00f6r\u00fc denilen, belirli bir gen ifadesinin, yeti\u015fkin h\u00fccreleri\u00a0 uyar\u0131lm\u0131\u015f pluripotent k\u00f6k h\u00fccrelere d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilece\u011fi ke\u015ffine dayan\u0131yor. Nobel \u00d6d\u00fcl\u00fc alm\u0131\u015f olan bu ke\u015fif, h\u00fccreleri kanserli ve\/veya \u00e7ok gen\u00e7 hale getirmeden h\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirmenin m\u00fcmk\u00fcn olup olmad\u0131\u011f\u0131 sorusunu g\u00fcndeme getirmi\u015fti.\u00a0<\/span><\/p>\n

Bu yeni \u00e7al\u0131\u015fmada ara\u015ft\u0131rmac\u0131lar, birle\u015fik haldeyken, h\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirebilen ve insan h\u00fccrelerini gen\u00e7le\u015ftirebilen molek\u00fclleri ara\u015ft\u0131rd\u0131lar. Ya\u015fl\u0131 ve ya\u015flanmakta olan h\u00fccrelerden gen\u00e7 h\u00fccreleri ay\u0131rmak i\u00e7in, transkripsiyona dayal\u0131 ya\u015flanma saatleri ve ger\u00e7ek zamanl\u0131 bir n\u00fckleositoplazmik protein b\u00f6l\u00fcmlendirme (NCC: nucleocytoplasmic protein compartmentalization) analizi de dahil olmak \u00fczere, y\u00fcksek hacimli h\u00fccre tabanl\u0131 analizler geli\u015ftirdiler. Heyecan verici bir ke\u015fifle, NCC\u2019yi onaracak ve genom \u00e7ap\u0131nda transkript g\u00f6r\u00fcn\u00fcmlerini tazeleyecek ve transkriptomik ya\u015flanmay\u0131 bir haftadan k\u0131sa bir s\u00fcrede tersine d\u00f6nd\u00fcrecek alt\u0131 kimyasal kokteyl belirlediler.<\/span><\/p>\n

Ya\u015flanma s\u00fcrecini tersine \u00e7evirmek ve terapilerin etkinli\u011fini test etmek i\u00e7in Sinclair Laboratuvar\u0131nda, h\u0131zla ya\u015flanacak \u015fekilde tasarlanm\u0131\u015f fareler kullan\u0131ld\u0131. Farelerden biri, epigenomu bozularak, karde\u015fine g\u00f6re y\u00fczde 150 daha ya\u015fl\u0131 hale getirildi.\u00a0<\/span><\/p>\n

\"\"
Ya\u015flanma s\u00fcrecini tersine \u00e7evirmek ve terapilerin etkinli\u011fini test etmek i\u00e7in Sinclair laboratuvar\u0131nda, h\u0131zla ya\u015flanacak \u015fekilde tasarlanm\u0131\u015f fareler kullan\u0131ld\u0131. Sa\u011fdaki fare, epigenomu bozularak, soldaki karde\u015fine g\u00f6re, y\u00fczde 150 daha ya\u015fl\u0131 hale getirildi. Foto\u011fraf: D. Sinclair, Harvard T\u0131p Okulu; 2023 Yang ve ark.<\/figcaption><\/figure>\n

Harvard ara\u015ft\u0131rmac\u0131lar\u0131 daha \u00f6nce \u00f6zel Yamanaka genlerini h\u00fccre i\u00e7ine viral olarak sokarak, kontrols\u00fcz h\u00fccre b\u00fcy\u00fcmesi olmadan h\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirmenin m\u00fcmk\u00fcn oldu\u011funu g\u00f6stermi\u015flerdi. Yap\u0131lm\u0131\u015f \u00e7al\u0131\u015fmalarla optik sinirle, beyin dokusuyla, b\u00f6brek ve kaslarla ilgili umut verici sonu\u00e7lar g\u00f6sterilmi\u015fti. Son d\u00f6nemde, s\u0131\u00e7anlarda ya\u015fam s\u00fcresinin uzamas\u0131yla ilgili ve maymunlarda g\u00f6rmenin iyile\u015fmesiyle ilgili \u00e7al\u0131\u015fmalar da yay\u0131mland\u0131.<\/span><\/p>\n

Rejeneratif t\u0131bb\u0131n ve t\u00fcm bedenin yenilenmesinin yolunu potansiyel olarak a\u00e7an bu yeni bulu\u015fun etkileri uzun erimli olacak. Ya\u015flanmaya kar\u015f\u0131 gen terapisine kimyasal bir alternatif geli\u015ftiren bu ara\u015ft\u0131rma bir devrim yaratabilir; ya\u015flanma tedavisi, yaralanmalar ve ya\u015fa ba\u011fl\u0131 hastal\u0131klarda d\u00fc\u015f\u00fck maliyetli ve h\u0131zl\u0131 geli\u015fim elde etme potansiyeli sunabilir. Nisan 2023\u2019de yay\u0131mlanan, maymunlarda k\u00f6rl\u00fc\u011f\u00fcn tersine \u00e7evrilmesine ili\u015fkin olumlu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131n\u0131 takiben, ya\u015f\u0131 tersine \u00e7eviren gen tedavisinde insan klinik deneyleri i\u00e7in laboratuvar haz\u0131rl\u0131klar\u0131 devam ediyor.<\/span><\/p>\n

Harvard T\u0131p Okulu\u2019ndaki Glenn Ya\u015flanma Ara\u015ft\u0131rmalar\u0131 Biyoloji Merkezi\u2019nde genetik profes\u00f6r\u00fc ve projenin ba\u015f\u0131ndaki biliminsan\u0131 olan David A. Sinclair, \u201cYak\u0131n zamana dek yapabildi\u011fimiz en iyi \u015fey ya\u015flanmay\u0131 yava\u015flatmakt\u0131. Ama yeni ke\u015fif bu s\u00fcreci tersine \u00e7evirebilece\u011fimizi de g\u00f6steriyor\u201d diyor ve ekliyor, \u201cBu, daha \u00f6nceleri, yayg\u0131n kullan\u0131m\u0131 s\u0131n\u0131rland\u0131r\u0131lm\u0131\u015f olan gen terapilerini gerektiriyordu.\u201d<\/span><\/p>\n

Harvard ekibi, ya\u015fa ba\u011fl\u0131 hastal\u0131klar\u0131n etkin bir \u015fekilde tedavi edilebildi\u011fi, yaralanmalar\u0131n daha etkin bir \u015fekilde onar\u0131labildi\u011fi ve b\u00fct\u00fcn v\u00fccut yenilenmesinin ger\u00e7e\u011fe d\u00f6n\u00fc\u015ft\u00fc\u011f\u00fc bir gelecek hayal ediyor. \u201cYeni ke\u015fif, g\u00f6rme yetene\u011fini geli\u015ftirmekten ya\u015fa ba\u011fl\u0131 bir\u00e7ok hastal\u0131\u011f\u0131 tedavi etmeye kadar geni\u015f bir uygulama alan\u0131nda, tek bir hapla ya\u015flanmay\u0131 geri d\u00f6nd\u00fcrme potansiyeli vaat ediyor\u201d diyorlar.\u00a0<\/span><\/p>\n

Reference:<\/strong> \u201cChemically induced reprogramming to reverse cellular aging\u201d by Jae-Hyun Yang, Christopher A. Petty, Thomas Dixon-McDougall, Maria Vina Lopez, Alexander Tyshkovskiy, Sun Maybury-Lewis, Xiao Tian, Nabilah Ibrahim, Zhili Chen, Patrick T. Griffin, Matthew Arnold, Jien Li, Oswaldo A. Martinez, Alexander Behn, Ryan Rogers-Hammond, Suzanne Angeli, Vadim N. Gladyshev and David A. Sinclair, 12 July 2023, Aging-US.<\/span><\/p>\n

DOI: 10.18632\/aging.204896<\/span><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

\u00c7eviren: Nal\u00e2n Mahsereci Ya\u015flanma ve ya\u015fa ba\u011fl\u0131 hastal\u0131klarla m\u00fccadelede \u00f6n\u00fcm\u00fczde yepyeni bir ufuk var art\u0131k. Harvard T\u0131p Okulu, Maine \u00dcniversitesi ve MIT\u2019den ara\u015ft\u0131rmac\u0131lar, \u00f6nc\u00fc bir \u00e7al\u0131\u015fmayla, h\u00fccresel ya\u015flanmay\u0131 tersine \u00e7evirmek i\u00e7in kimyasal bir y\u00f6ntem geli\u015ftirdiler. \u00c7al\u0131\u015fma, h\u00fccreleri gen\u00e7 h\u00fccreler olarak yeniden programlamay\u0131 hedefleyen ilk kimyasal yakla\u015f\u0131m\u0131 i\u00e7eriyor. \u00d6nceden bunun ancak g\u00fc\u00e7l\u00fc gen terapileriyle m\u00fcmk\u00fcn olabilece\u011fi […]<\/p>\n","protected":false},"author":470,"featured_media":58856,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[19,21,4747,1,3729,4696],"tags":[],"class_list":["post-58855","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bilim-gundemi","category-biyoloji","category-biyoteknoloji","category-genel","category-genetik","category-tip"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t