{"id":8534,"date":"2007-12-01T00:02:22","date_gmt":"2007-11-30T22:02:22","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=8534"},"modified":"2017-07-17T12:20:09","modified_gmt":"2017-07-17T09:20:09","slug":"adenovirus-5-in-mucadelesi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2007\/12\/01\/adenovirus-5-in-mucadelesi","title":{"rendered":"Adenovir\u00fcs-5\u2019 in m\u00fccadelesi"},"content":{"rendered":"

Ekim ay\u0131n\u0131n ortalar\u0131nda ara\u015ft\u0131rmac\u0131lar, Merck\u2019in HIV i\u00e7in geli\u015ftirdi\u011fi a\u015f\u0131n\u0131n klinik denemelerdeki ba\u015far\u0131s\u0131zl\u0131\u011f\u0131n\u0131 ve baz\u0131 kat\u0131l\u0131mc\u0131lara vir\u00fcs bula\u015ft\u0131\u011f\u0131n\u0131 a\u00e7\u0131klad\u0131lar. B\u00f6ylelikle bilim insanlar\u0131, bir immun cevab\u0131 uyarmak i\u00e7in benzer stratejileri kullanan a\u015f\u0131lar\u0131n denemelerinde \u00e7\u0131kabilecek vir\u00fcs bula\u015fma ihtimalini dikkate almak zorunda kald\u0131lar. Nature<\/em> dergisinin kas\u0131m say\u0131s\u0131ndaki habere g\u00f6re, a\u015f\u0131 ile ilgili denemelerin bir s\u00fcreli\u011fine ask\u0131ya al\u0131nd\u0131\u011f\u0131 da bildiriliyor.<\/p>\n

A\u015f\u0131, zay\u0131flat\u0131lm\u0131\u015f bir viral vekt\u00f6r\u00fcn ta\u015f\u0131d\u0131\u011f\u0131 3 adet HIV genini i\u00e7eriyor. Asl\u0131nda,\u00a0 ne HIV genleri ne de vekt\u00f6r, enfeksiyona sebep olan adenovir\u00fcs-5 isimli \u201ccommon-cold\u201d vir\u00fcsden yap\u0131lmad\u0131. Buna ra\u011fmen g\u00f6r\u00fcnen o ki, adenovir\u00fcs-5\u2019e kar\u015f\u0131 \u00f6nceden ba\u011f\u0131\u015f\u0131kl\u0131k kazanm\u0131\u015f olan hastalara a\u015f\u0131 yap\u0131ld\u0131\u011f\u0131 zaman HIV-pozitif olmalar\u0131 daha kolayla\u015f\u0131yor.<\/p>\n

Adenovir\u00fcse kar\u015f\u0131 y\u00fcksek antikor seviyesine sahip erkek hastalar\u0131n 392 tanesinden 21\u2019i a\u015f\u0131dan sonra enfekte olurken bu oran plasebo grubunda 386 ki\u015fiden 9 ki\u015fi olarak g\u00f6r\u00fcld\u00fc. \u0130lk bak\u0131\u015fta, adenovir\u00fcs-5 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 olmayan (daha \u00f6nce vir\u00fcse maruz kalmam\u0131\u015f) erkeklerde a\u015f\u0131n\u0131n enfeksiyon oran\u0131na bir etkisi olmad\u0131\u011f\u0131 san\u0131l\u0131yor, fakat bu sonucun istatistiksel olarak anlams\u0131z oldu\u011funu d\u00fc\u015f\u00fcnenler de var.<\/p>\n

\u015eimdilerde, bilim insanlar\u0131 enfeksiyon riskinin a\u015f\u0131da kullan\u0131lan vekt\u00f6rden mi yoksa adenovir\u00fcs-5 ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131ndan m\u0131 geldi\u011fini ara\u015ft\u0131r\u0131yorlar. \u0130mmunologlara g\u00f6re, a\u015f\u0131 olmak aktive olmu\u015f CD4 h\u00fccrelerinin \u00fcretimini ge\u00e7ici bir s\u00fcre i\u00e7in tetikliyor. Tabii bu teori beraberinde bir\u00e7ok soruyu da getiriyor.<\/p>\n

Bethesda Ulusal Sa\u011fl\u0131k Estit\u00fcs\u00fc\u2019nden Dr. Gary Nabel\u2019a g\u00f6re vekt\u00f6re kar\u015f\u0131 d\u00fc\u015f\u00fck seviyede ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 olan ki\u015filerde adenovir\u00fcs\u20135 tabanl\u0131 a\u015f\u0131lar\u0131n kullan\u0131m\u0131na s\u0131n\u0131rlama getirmek, bir \u00e7\u00f6z\u00fcm olabilir.<\/p>\n

D\u00fcnyada yakla\u015f\u0131k 40 milyon AIDS hastas\u0131 bulunuyor. Bununla beraber hastal\u0131\u011f\u0131n tan\u0131mlanmas\u0131ndan sonra y\u0131lda ortalama 1 milyon ki\u015finin vir\u00fcs nedeniyle hayat\u0131n\u0131 kaybetti\u011fi biliniyor. A\u015f\u0131n\u0131n ba\u015far\u0131s\u0131zl\u0131\u011f\u0131 hem \u00fcretici firman\u0131n hedefledi\u011fi pazar pay\u0131na ula\u015famamas\u0131 nedeniyle firmay\u0131, hem de tedavi umuduyla ya\u015fayan hastalar\u0131 d\u00fc\u015f k\u0131r\u0131kl\u0131\u011f\u0131na soktu.<\/p>\n

 <\/p>\n","protected":false},"excerpt":{"rendered":"

Ekim ay\u0131n\u0131n ortalar\u0131nda ara\u015ft\u0131rmac\u0131lar, Merck\u2019in HIV i\u00e7in geli\u015ftirdi\u011fi a\u015f\u0131n\u0131n klinik denemelerdeki ba\u015far\u0131s\u0131zl\u0131\u011f\u0131n\u0131 ve baz\u0131 kat\u0131l\u0131mc\u0131lara vir\u00fcs bula\u015ft\u0131\u011f\u0131n\u0131 a\u00e7\u0131klad\u0131lar. B\u00f6ylelikle bilim insanlar\u0131, bir immun cevab\u0131 uyarmak i\u00e7in benzer stratejileri kullanan a\u015f\u0131lar\u0131n denemelerinde \u00e7\u0131kabilecek vir\u00fcs bula\u015fma ihtimalini dikkate almak zorunda kald\u0131lar. Nature dergisinin kas\u0131m say\u0131s\u0131ndaki habere g\u00f6re, a\u015f\u0131 ile ilgili denemelerin bir s\u00fcreli\u011fine ask\u0131ya al\u0131nd\u0131\u011f\u0131 da bildiriliyor. […]<\/p>\n","protected":false},"author":472,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[84,21,231,35,33],"tags":[197,262,300,203],"class_list":["post-8534","post","type-post","status-publish","format-standard","hentry","category-46-sayi","category-biyoloji","category-molekuler-biyoloji-ve-genetik","category-noroloji","category-saglik-bilimleri","tag-biyoloji","tag-biyoteknoloji","tag-hastaliklar","tag-tibbi-biyoloji"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t