Harvard K\u00f6k H\u00fccre Enstit\u00fcs\u00fc biliminsanlar\u0131 ilk kez kan damarlar\u0131n\u0131n i\u00e7 y\u00fczeyini saran vaskular endotel h\u00fccreler diye adland\u0131r\u0131lan h\u00fccreleri olu\u015fturmay\u0131 ba\u015fard\u0131lar. Bunun i\u00e7in h\u00fccrelerin fonksiyonu ile ilgili daha fazla detay\u0131 ortaya koyan insan ind\u00fcklenmi\u015f (uyar\u0131lm\u0131\u015f) pluripotent k\u00f6k h\u00fccrelerini (inducedpluripotentstemcell- iPSC) kulland\u0131lar. Ara\u015ft\u0131rmac\u0131lar iPSC\u2019den t\u00fcretilmi\u015f endotel h\u00fccrelerinin, kan ak\u0131\u015f\u0131n\u0131 taklit eden bir mekanik kuvvet olu\u015fturarak belirli h\u00fccre tiplerine farkl\u0131la\u015fmas\u0131n\u0131 uyard\u0131lar. \u015e\u00f6yle ki, h\u00fccreler daha g\u00fc\u00e7l\u00fc bir ak\u0131\u015f hissettiklerinde atardamara, daha zay\u0131f bir ak\u0131\u015f hissettiklerinde ise toplardamara d\u00f6n\u00fc\u015ft\u00fcler.<\/p>\n
Ara\u015ft\u0131rman\u0131n y\u00fcr\u00fct\u00fcc\u00fcs\u00fc ve Harvard K\u00f6k H\u00fccre Enstit\u00fcs\u00fc\u2019ne ba\u011fl\u0131 \u00f6\u011fretim g\u00f6revlisi Do\u00e7. Dr. Guillermo Garc\u00eda-Cardena \u201cBizim i\u00e7in \u00f6zellikle heyecan verici olan durum bu h\u00fccrelerin \u00e7ok temel olarak biyomekanik i\u015faretlere yan\u0131t verdiklerini ke\u015ffetmemiz oldu. H\u00fccreleri, endotel h\u00fccrelerde iltihab\u0131 tetikleyen ateropron ak\u0131\u015f\u0131na maruz b\u0131rakarak dola\u015f\u0131m sisteminde var olan ve ateroskleroz gibi hastal\u0131klardan etkilendi\u011fini bildi\u011fimiz h\u00fccre tiplerine direkt olarak farkl\u0131la\u015ft\u0131rabildik.\u201d diyor.<\/p>\n
Garc\u00eda-Cardena atar damarlarda olu\u015fan plaklar\u0131n insan iPSC\u2019den t\u00fcretilmi\u015f endotel h\u00fccrelerini kullanarak modellenmesi ve bu plak olu\u015fumunu engelleyebilecek potansiyel ila\u00e7 geli\u015ftirilmesi \u00fczerine \u00e7al\u0131\u015fmaktad\u0131r. Garc\u00eda-Cardena\u2019n\u0131n grubundan Harvard \u00dcniversitesi M\u00fchendislik ve Uygulamal\u0131 Bilimler Fak\u00fcltesi mezunu William Adams, iPSC\u2019den t\u00fcretilmi\u015f endotel h\u00fccrelerinin \u00a0iltihabi cevapla olan ba\u011flant\u0131s\u0131, damar d\u0131\u015f\u0131na s\u0131zan kan\u0131n tutulmas\u0131 ve kan\u0131n p\u0131ht\u0131la\u015fmas\u0131n\u0131n engellenmesi gibi normal v\u00fccutta bulunan olgun endotel h\u00fccrenin yapabildi\u011fi \u00fc\u00e7 kritik fonksiyonu ger\u00e7ekle\u015ftirebildi\u011fini g\u00f6sterdi.<\/p>\n
Bu bilgiler do\u011frultusunda Garc\u00eda-Cardena\u2019n\u0131n \u00e7al\u0131\u015fmas\u0131 Stem Cell Reports<\/em> dergisinde bu ay bas\u0131ld\u0131. \u00c7al\u0131\u015fman\u0131n sakl\u0131 kalm\u0131\u015f di\u011fer ilgin\u00e7 sonucu da b\u00f6brek hastalar\u0131nda diyaliz tedavisi ve akci\u011fer yetmezli\u011fi tedavisi s\u0131ras\u0131nda kullan\u0131lan heparin ihtiyac\u0131n\u0131n d\u00fc\u015f\u00fcr\u00fclmesi ve hatta tamam\u0131yla bertaraf edilmesi ihtimalinin olabilmesidir.<\/p>\n Geleneksel olarak diyalize giren hastalarda diyaliz makinesi boyunca yap\u0131lan d\u00f6ng\u00fcde kan\u0131n p\u0131ht\u0131la\u015fmas\u0131n\u0131 engellemek i\u00e7in heparin kullan\u0131lmaktad\u0131r. Ancak heparin, kan\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde incelterek p\u0131ht\u0131la\u015fmay\u0131 engellerken kan kayb\u0131na, i\u00e7 kanamaya ve iyile\u015fme s\u00fcrecinin olumsuz etkilenmesine neden olabilmektedir.<\/p>\n \u201ciPSC\u2019den t\u00fcretilmi\u015f h\u00fccreler p\u0131ht\u0131la\u015fma \u00f6nleyici y\u00fczey olarak i\u015flev g\u00f6rebilmektedir. Gelecekte hastalardan doku \u00f6rne\u011fi alarak ind\u00fcklenmi\u015f pluripotent k\u00f6k h\u00fccrelerini olu\u015fturaca\u011f\u0131z ve sonras\u0131nda v\u00fccut d\u0131\u015f\u0131nda kalan cihaz\u0131 hastan\u0131n kendi endotel h\u00fccresi ile kaplayaca\u011f\u0131z. B\u00f6ylelikle hasta d\u00fczenli heparin al\u0131mlar\u0131na gerek duymadan cihazla birlikte evine gidebilecek.\u201d diyerek s\u00f6zlerini noktal\u0131yor Garc\u00eda-Cardena.<\/p>\n","protected":false},"excerpt":{"rendered":" Harvard K\u00f6k H\u00fccre Enstit\u00fcs\u00fc biliminsanlar\u0131 ilk kez kan damarlar\u0131n\u0131n i\u00e7 y\u00fczeyini saran vaskular endotel h\u00fccreler diye adland\u0131r\u0131lan h\u00fccreleri olu\u015fturmay\u0131 ba\u015fard\u0131lar. Bunun i\u00e7in h\u00fccrelerin fonksiyonu ile ilgili daha fazla detay\u0131 ortaya koyan insan ind\u00fcklenmi\u015f (uyar\u0131lm\u0131\u015f) pluripotent k\u00f6k h\u00fccrelerini (inducedpluripotentstemcell- iPSC) kulland\u0131lar. Ara\u015ft\u0131rmac\u0131lar iPSC\u2019den t\u00fcretilmi\u015f endotel h\u00fccrelerinin, kan ak\u0131\u015f\u0131n\u0131 taklit eden bir mekanik kuvvet olu\u015fturarak belirli h\u00fccre […]<\/p>\n","protected":false},"author":755,"featured_media":8853,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[152,19,21,231],"tags":[424,541],"class_list":["post-8852","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-115-sayi","category-bilim-gundemi","category-biyoloji","category-molekuler-biyoloji-ve-genetik","tag-kok-hucre","tag-molekuler-biyoloji"],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/8852","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/users\/755"}],"replies":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/comments?post=8852"}],"version-history":[{"count":0,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/posts\/8852\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media\/8853"}],"wp:attachment":[{"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/media?parent=8852"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/categories?post=8852"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/bilimvegelecek.com.tr\/index.php\/wp-json\/wp\/v2\/tags?post=8852"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}