{"id":9650,"date":"2010-01-01T18:19:17","date_gmt":"2010-01-01T16:19:17","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=9650"},"modified":"2021-04-04T15:38:39","modified_gmt":"2021-04-04T12:38:39","slug":"yapay-kirmizi-kan-hucresi-uretildi","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2010\/01\/01\/yapay-kirmizi-kan-hucresi-uretildi","title":{"rendered":"Yapay k\u0131rm\u0131z\u0131 kan h\u00fccresi \u00fcretildi"},"content":{"rendered":"<p>California (Santa Barbara) \u00dcniversitesi\u2019nden Mitragotri ve grubu ile Michigan \u00dcniversitesi\u2019nden meslekta\u015flar\u0131, halkasal bir polimer \u00fcretip \u00fczerini dokuz kat hemoglobin ve di\u011fer kan proteinleri ile kaplad\u0131lar. Daha sonra, kal\u0131p olarak kulland\u0131klar\u0131 halkasal polimeri uzakla\u015ft\u0131rd\u0131lar. Olu\u015fan partik\u00fcller do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin sahip oldu\u011fu esnekli\u011fe ve b\u00fcy\u00fckl\u00fc\u011fe sahipti. Ayr\u0131ca do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccreleri kadar oksijen ta\u015f\u0131yabiliyordu. B\u00f6ylece do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin temel g\u00f6rev ve \u00f6zelliklerini taklit edebilen yapay k\u0131rm\u0131z\u0131 kan h\u00fccresi elde etmeyi ba\u015fard\u0131lar. Yapay k\u0131rm\u0131z\u0131 kan h\u00fccreleri \u00fcretildikten bir hafta sonra bile oksijen ta\u015f\u0131ma kapasitesinin y\u00fczde 90\u2019\u0131na sahipti.<br \/>\nEsneklik, do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccrelerinde oldu\u011fu gibi, yapay k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin de kendi \u00e7aplar\u0131ndan daha k\u00fc\u00e7\u00fck \u00e7apa sahip kanallarda hareket etmelerine, ak\u0131\u015f h\u0131z\u0131na ba\u011fl\u0131 olarak esnemelerine ve tekrar eski disk \u015fekillerine d\u00f6nmelerine olanak sa\u011flamaktad\u0131r. Daha \u00f6nceki \u00e7al\u0131\u015fmalarda, terapatik ve tan\u0131 ajanlar\u0131n\u0131 ta\u015f\u0131mak i\u00e7in geleneksel yollarla yap\u0131lan polimer tabanl\u0131 biyo-malzemelerde esneklik \u00f6zelli\u011fi bulunmuyordu.<br \/>\nYapay k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin terapatik ila\u00e7lar\u0131n da\u011f\u0131t\u0131m\u0131n\u0131 ve ila\u00e7lar\u0131n kontroll\u00fc sal\u0131n\u0131m\u0131n\u0131 ba\u015far\u0131yla ger\u00e7ekle\u015ftirdikleri g\u00f6zlendi. Ayr\u0131ca g\u00f6r\u00fcnt\u00fcl\u00fc tan\u0131da daha iyi \u00e7\u00f6z\u00fcn\u00fcrl\u00fck i\u00e7in kullan\u0131lan kontrast maddelerin v\u00fccut i\u00e7inde da\u011f\u0131l\u0131m\u0131n\u0131 etkili \u015fekilde yapt\u0131klar\u0131 g\u00f6r\u00fcld\u00fc.<br \/>\nSa\u011fl\u0131kl\u0131 k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin \u015fekil ve \u00f6zelliklerini taklit eden partik\u00fcllerin \u00fcretilmesinde kullan\u0131lan bu tekni\u011fin, orak h\u00fccre anemisi gibi hastal\u0131kl\u0131 h\u00fccrelerin \u015fekil ve \u00f6zelliklerini de taklit edebilen partik\u00fcllerin \u00fcretiminde de kullan\u0131labilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir. Bu yolla \u00fcretilecek yapay hastal\u0131kl\u0131 h\u00fccrelerin, h\u00fccre bozukluklar\u0131n\u0131n nas\u0131l geli\u015ftiklerinin ve sa\u011fl\u0131kl\u0131 h\u00fccreleri nas\u0131l etkilediklerinin anla\u015f\u0131lmas\u0131nda \u00f6nemli katk\u0131lar sunaca\u011f\u0131 tahmin edilmektedir.<br \/>\n<em>(Kaynak: Nishit Doshi, Alisar S. Zahr, Srijanani Bhaskar, Joerg Lahann, and Samir Mitragotri. <strong>Red blood cell-mimicking synthetic biomaterial particles<\/strong>. <\/em><em>Proceedings of the National Academy of Sciences<\/em><em>, 2009; DOI: 10.1073\/pnas.0907127106)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>California (Santa Barbara) \u00dcniversitesi\u2019nden Mitragotri ve grubu ile Michigan \u00dcniversitesi\u2019nden meslekta\u015flar\u0131, halkasal bir polimer \u00fcretip \u00fczerini dokuz kat hemoglobin ve di\u011fer kan proteinleri ile kaplad\u0131lar. Daha sonra, kal\u0131p olarak kulland\u0131klar\u0131 halkasal polimeri uzakla\u015ft\u0131rd\u0131lar. Olu\u015fan partik\u00fcller do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccrelerinin sahip oldu\u011fu esnekli\u011fe ve b\u00fcy\u00fckl\u00fc\u011fe sahipti. Ayr\u0131ca do\u011fal k\u0131rm\u0131z\u0131 kan h\u00fccreleri kadar oksijen ta\u015f\u0131yabiliyordu. B\u00f6ylece do\u011fal [&hellip;]<\/p>\n","protected":false},"author":348,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[108,19,38,33],"tags":[],"class_list":["post-9650","post","type-post","status-publish","format-standard","hentry","category-71-sayi","category-bilim-gundemi","category-dergi-sayilari","category-saglik-bilimleri"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 4.9.8 - aioseo.com -->\n\t<meta name=\"robots\" content=\"max-image-preview:large\" \/>\n\t<meta name=\"author\" content=\"H\u00fcseyin Tayran\"\/>\n\t<link rel=\"canonical\" href=\"https:\/\/bilimvegelecek.com.tr\/index.php\/2010\/01\/01\/yapay-kirmizi-kan-hucresi-uretildi\" \/>\n\t<meta name=\"generator\" content=\"All in One SEO (AIOSEO) 4.9.8\" \/>\n\t\t<meta property=\"og:locale\" content=\"tr_TR\" \/>\n\t\t<meta property=\"og:site_name\" content=\"Bilim ve Gelecek\" \/>\n\t\t<meta property=\"og:type\" content=\"article\" \/>\n\t\t<meta property=\"og:title\" content=\"Yapay k\u0131rm\u0131z\u0131 kan h\u00fccresi \u00fcretildi | Bilim ve Gelecek\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/bilimvegelecek.com.tr\/index.php\/2010\/01\/01\/yapay-kirmizi-kan-hucresi-uretildi\" \/>\n\t\t<meta property=\"fb:app_id\" content=\"2104805563100892\" \/>\n\t\t<meta property=\"fb:admins\" content=\"1250955469\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2010-01-01T16:19:17+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2021-04-04T12:38:39+00:00\" \/>\n\t\t<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/bilimvegelecekdergisi\/\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n\t\t<meta name=\"twitter:site\" content=\"@bilimvegelecek\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Yapay k\u0131rm\u0131z\u0131 kan h\u00fccresi \u00fcretildi | Bilim ve Gelecek\" \/>\n\t\t<script type=\"application\/ld+json\" class=\"aioseo-schema\">\n\t\t\t{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/index.php\\\/2010\\\/01\\\/01\\\/yapay-kirmizi-kan-hucresi-uretildi#article\",\"name\":\"Yapay k\\u0131rm\\u0131z\\u0131 kan h\\u00fccresi \\u00fcretildi | Bilim ve Gelecek\",\"headline\":\"Yapay k\\u0131rm\\u0131z\\u0131 kan h\\u00fccresi \\u00fcretildi\",\"author\":{\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/index.php\\\/author\\\/htayran#author\"},\"publisher\":{\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/#organization\"},\"image\":{\"@type\":\"ImageObject\",\"url\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/wp-content\\\/uploads\\\/2018\\\/02\\\/bilim-ve-gelecek-logo-1.png\",\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/#articleImage\",\"width\":272,\"height\":90,\"caption\":\"Bilim ve Gelecek Dergisi\"},\"datePublished\":\"2010-01-01T18:19:17+02:00\",\"dateModified\":\"2021-04-04T15:38:39+03:00\",\"inLanguage\":\"tr-TR\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/index.php\\\/2010\\\/01\\\/01\\\/yapay-kirmizi-kan-hucresi-uretildi#webpage\"},\"isPartOf\":{\"@id\":\"https:\\\/\\\/bilimvegelecek.com.tr\\\/index.php\\\/2010\\\/01\\\/01\\\/yapay-kirmizi-kan-hucresi-uretildi#webpage\"},\"articleSection\":\"71. 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