{"id":9803,"date":"2011-03-01T16:56:03","date_gmt":"2011-03-01T14:56:03","guid":{"rendered":"http:\/\/109.232.216.219\/~bilimvegelecek\/?p=9803"},"modified":"2017-05-21T16:59:00","modified_gmt":"2017-05-21T13:59:00","slug":"kirmizi-sarap-rapamisinin-anti-tumor-etkisini-artiriyor","status":"publish","type":"post","link":"https:\/\/bilimvegelecek.com.tr\/index.php\/2011\/03\/01\/kirmizi-sarap-rapamisinin-anti-tumor-etkisini-artiriyor","title":{"rendered":"K\u0131rm\u0131z\u0131 \u015farap Rapamisin\u2019in anti-t\u00fcm\u00f6r etkisini art\u0131r\u0131yor"},"content":{"rendered":"

Cleveland Clinic’s Lerner Research Institute <\/em>ara\u015ft\u0131rmac\u0131lar\u0131, k\u0131rm\u0131z\u0131 \u015farapta bulunan, tek ba\u015f\u0131na rapamisine kar\u015f\u0131 diren\u00e7 g\u00f6steren meme kanser h\u00fccreleri \u00fczerinde rapamisin ile birlikte kullan\u0131ld\u0131\u011f\u0131nda t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 etkiye sahip Resveratrol isimli bir bile\u015fik ke\u015ffettiler.<\/p>\n

Cancer Letters<\/em> dergisinde yay\u0131nlanan \u00e7al\u0131\u015fma, bu tedavi edici bile\u015fimde PTEN t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genin resveratrol\u2019\u00fcn anti-t\u00fcm\u00f6r etkilerine katk\u0131da bulundu\u011funu belirtmekte.<\/p>\n

Genomic Medicine Institute of Cleveland Clinic’s Lerner Research Institute <\/em>Ba\u015fkan\u0131 Charis Eng, bir\u00e7ok do\u011fal bile\u015fimde bulunan kemopreventif ila\u00e7 olan Resveratrol ile Rapamisinin birle\u015ftirilmi\u015f etkisini meme kanser h\u00fccrelerinde \u00e7al\u0131\u015fmak i\u00e7in ekibine \u00f6nc\u00fcl\u00fck etmi\u015f. \u00c7al\u0131\u015fma, bu iki ilac\u0131n meme kanser h\u00fccre sinyal ileti\u015fiminde ve b\u00fcy\u00fcmesindeki etkisini g\u00f6stermekte.<\/p>\n

Eng, \u201cRapamisin kanser tedavisinde uzun zamand\u0131r kullan\u0131lmakta. Maalesef, bir s\u00fcre sonra kanser h\u00fccreleri Rapamisine kar\u015f\u0131 diren\u00e7 geli\u015ftirmektedir.\u201d a\u00e7\u0131klamas\u0131n\u0131 yapt\u0131. \u201cBulgular\u0131m\u0131z, Resveratrol\u00fcn, laboratuvar ortam\u0131nda meme kanserinde Rapamisin-temelli ila\u00e7 direncini hafifletti\u011fini g\u00f6stermi\u015ftir. E\u011fer bu bulgular klinikte de do\u011frulu\u011funu kan\u0131tlarsa, kanser tedavisi i\u00e7in rapamisin almadan \u00f6nce bir bardak k\u0131rm\u0131z\u0131 \u015farap i\u00e7mek veya\u00a0 k\u0131rm\u0131z\u0131 \u015faraptan daha \u00e7ok resveratrol i\u00e7eri\u011fine sahip bir kase pi\u015fmi\u015f yer f\u0131st\u0131\u011f\u0131 yemek temkinli bir yakla\u015f\u0131m olacakt\u0131r.\u201d<\/p>\n

Organ transplantasyonunda doku reddini \u00f6nlemek i\u00e7in immunos\u00fcpresif (immun sistem bask\u0131lay\u0131c\u0131) ila\u00e7 olarak kullan\u0131lan Rapamisin, meme kanserine kar\u015f\u0131 anti-t\u00fcm\u00f6r etkisi i\u00e7in kullan\u0131lmakta. K\u0131rm\u0131z\u0131 \u00fcz\u00fcm y\u00fczeyinde bulunan ve k\u0131rm\u0131z\u0131 \u015farab\u0131n bir par\u00e7as\u0131 olan Resveratrol bir \u00e7e\u015fit polifenol ve h\u00fccresel terapide \u00e7oklu kullan\u0131m i\u00e7in d\u00fc\u015f\u00fcn\u00fclmekte.<\/p>\n

T\u00fcm\u00f6r bask\u0131lamada bir potansiyel olmas\u0131na ra\u011fmen, Rapamisinin\"\" etkinli\u011fi \u00e7e\u015fitli meme kanser h\u00fccreleri aras\u0131nda belirgin \u015fekilde de\u011fi\u015fmekte. Resveratrol ve Rapamisinin tek ba\u015f\u0131na ve kombine halde etkileri, \u00fc\u00e7 insan meme kanseri h\u00fccre hatt\u0131n\u0131n b\u00fcy\u00fcmesi \u00fczerinde de\u011ferlendirilmi\u015f. Rapamisin, Resveratrol ve bu ajanlar\u0131n kombinasyonlar\u0131 doza-ba\u011f\u0131ml\u0131 olgularda h\u00fccre b\u00fcy\u00fcmesini inhibe etmi\u015f. Test edilen \u00fc\u00e7 h\u00fccre hatt\u0131nda da, Resveratrol ve Rapamisinin d\u00fc\u015f\u00fck konsantrasyonlar\u0131n\u0131n varl\u0131\u011f\u0131 b\u00fcy\u00fcmeyi y\u00fczde 50 oran\u0131nda inhibe etmek i\u00e7in yeterli olmu\u015f. Hen\u00fcz erken olsa da, bu bulgular Resveratrol\u00fcn geleneksel kemoterapiye ek olarak g\u00fc\u00e7l\u00fc tamamlay\u0131c\u0131 bir ila\u00e7 oldu\u011funu g\u00f6sterebilir.<\/p>\n

Kaynak: <\/strong>Xin He, Yu Wang, Jinhong Zhu, Mohammed Orloff, Charis Eng. Resveratrol enhances the anti-tumor activity of the mTOR inhibitor rapamycin in multiple breast cancer cell lines mainly by suppressing rapamycin-induced AKT signaling<\/strong>.<\/strong> Cancer Letters<\/em>, 2011; 301 (2) : 168 DOI: 10.1016\/j.canlet.2010.11.012<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cleveland Clinic’s Lerner Research Institute ara\u015ft\u0131rmac\u0131lar\u0131, k\u0131rm\u0131z\u0131 \u015farapta bulunan, tek ba\u015f\u0131na rapamisine kar\u015f\u0131 diren\u00e7 g\u00f6steren meme kanser h\u00fccreleri \u00fczerinde rapamisin ile birlikte kullan\u0131ld\u0131\u011f\u0131nda t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 etkiye sahip Resveratrol isimli bir bile\u015fik ke\u015ffettiler. Cancer Letters dergisinde yay\u0131nlanan \u00e7al\u0131\u015fma, bu tedavi edici bile\u015fimde PTEN t\u00fcm\u00f6r bask\u0131lay\u0131c\u0131 genin resveratrol\u2019\u00fcn anti-t\u00fcm\u00f6r etkilerine katk\u0131da bulundu\u011funu belirtmekte. Genomic Medicine Institute of […]<\/p>\n","protected":false},"author":801,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[122,19],"tags":[444,640],"class_list":["post-9803","post","type-post","status-publish","format-standard","hentry","category-85-sayi","category-bilim-gundemi","tag-kanser","tag-tip"],"acf":[],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t